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Targeting dermatophyte Cdc42 and Rac GTPase signaling to hinder hyphal elongation and virulence

Summary: The development of antifungal drugs requires novel molecular targets due to limited treatment options and drug resistance. Through chemical screening and establishment of a novel genetic technique to repress gene expression in Trichophyton rubrum, the primary causal fungus of dermatophytosi...

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Príomhchruthaitheoirí: Masaki Ishii, Yasuhiko Matsumoto, Tsuyoshi Yamada, Hideko Uga, Toshiaki Katada, Shinya Ohata
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2024-06-01
Sraith:iScience
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Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2589004224013646
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