Identification of computationally designed skeletal and cardiac promoters with high specificity across AAV delivery routes

Abstract Background Precise control of transgene expression is essential for safe and effective AAV gene therapies. While capsid engineering has advanced tissue targeting, progress in developing regulatory elements that confine expression to specific tissues has lagged. This gap limits the ability t...

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Hlavní autoři:	Nicole Zielinska, Erin L. Howard, Brenna A. Y. Stevens, Melanie M. Goens, Cici Yang, Elena S. B. Campbell, Madison E. Hughes, Yanlong Pei, Dinghai Zheng, D. Benjamin Gordon, Alec A. K. Nielsen, Raja R. Srinivas, Jeff L. Caswell, Luis G. Arroyo, Sarah K. Wootton
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-03-01
Edice:	BMC Biotechnology
Témata:	AAV Tissue-specific Promoters Algorithm Targeted Cardiac muscle
On-line přístup:	https://doi.org/10.1186/s12896-026-01141-1
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