A refined analysis of Neanderthal-introgressed sequences in modern humans with a complete reference genome

Abstract Background Leveraging long-read sequencing technologies, the first complete human reference genome, T2T-CHM13, corrects assembly errors in previous references and resolves the remaining 8% of the genome. While studies on archaic admixture in modern humans have so far relied on the GRCh37 re...

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Hauptverfasser:	Shen-Ao Liang, Tianxin Ren, Jiayu Zhang, Jiahui He, Xuankai Wang, Xinrui Jiang, Yuan He, Rajiv C. McCoy, Qiaomei Fu, Joshua M. Akey, Yafei Mao, Lu Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-02-01
Schriftenreihe:	Genome Biology
Schlagworte:	T2T-CHM13 Archaic admixture Adaptive introgression Database Complete human genome sequence
Online-Zugang:	https://doi.org/10.1186/s13059-025-03502-z
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