Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics

The blood-brain barrier (BBB), while being the gatekeeper of the central nervous system (CNS), is a bottleneck for the treatment of neurological diseases. Unfortunately, most of the biologicals do not reach their brain targets in sufficient quantities. The antibody targeting of receptor-mediated tra...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Laura Rué, Tom Jaspers, Isabelle M. S. Degors, Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-06-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	nanobody VHH transferrin receptor blood-brain barrier receptor-mediated transcytosis
Online-Zugang:	https://www.mdpi.com/1999-4923/15/6/1748
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