MARCH8 promotes the proteasomal degradation of foot-and-mouth disease virus VP1, VP2, and VP3 to negatively regulate viral replication

Abstract The host cell membrane-associated RING-CH8 protein (MARCH8) functions as an antiviral host factor by targeting viral envelope glycoproteins. Foot-and-mouth disease virus (FMDV) is a non-enveloped, positive-sense, single-stranded RNA virus. The potential impact of MARCH8 on FMDV replication...

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Autores principales:	Mengge Yin, Xiangmin Li, Min Zhang, Qiongqiong Zhao, Haoyuan Wang, Huiyan Zhang, Zengjun Lu, Ping Qian
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-04-01
Colección:	Veterinary Research
Materias:	Membrane-associated RING-CH8 protein foot-and-mouth disease virus restriction factor proteasomal degradation K33-linked polyubiquitination
Acceso en línea:	https://doi.org/10.1186/s13567-025-01521-z
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