Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci

Summary: Most genetic loci linked to polygenic traits are in non-coding regions, with complex regulation and linkage disequilibrium (LD), complicating causal variant and gene prioritization. We used multiplexed single-cell CRISPR interference and activation perturbations to investigate cis-regulator...

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Dettagli Bibliografici

Autori principali:	Ke Zhao, Yao Zhou, Xueqi Wang, Zhao Wang, Xinran Xu, Yichen Chen, Lin Zhao, Chengyue Wu, Jianhua Wang, Hongcheng Yao, Xin Cheng, Wei Wang, Xinlei Chu, Weixin Wang, Xianfu Yi, Yupeng Chen, Miaoxin Li, Wange Lu, Kexin Chen, Pak Chung Sham, Dandan Huang, Jing Zhang, Mulin Jun Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-11-01
Serie:	Cell Genomics
Soggetti:	eQTL Perturb-seq regulatory element CRISPR linkage disequilibrium
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2666979X25002381
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