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Design, synthesis and antiproliferative activity evaluation of new 3,7-disubstituted pyrrolo[2,3-c]pyridines

A number of 3,7-disubstituted 6-azaindoles were designed and synthesized starting from the readily accessible 2-chloro-3-nitro-4-picoline. The target compounds were tested for their antiproliferative activity against HT-1080, A431 and A549 cancer cell lines in comparison to the normal human AG01523...

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Principais autores: Marianthi Zografistou, Maria Georgiou, Eleni V. Mikropoulou, Maria Halabalaki, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos, Eleni Mavrogonatou, Harris Pratsinis, Dimitris Kletsas
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-04-01
Serier:European Journal of Medicinal Chemistry Reports
Fag:
Synthesis
Azaindole
Purine analogue
Cytotoxicity
cell cycle
Online adgang:http://www.sciencedirect.com/science/article/pii/S2772417426000075
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