Molecular profiling of the Basal-like intrinsic molecular subtype in primary ER-positive HER2-negative breast cancer

Abstract Background The clinical management of ER-positive/HER2-negative (ERpHER2n) breast cancer is complicated by a heterogeneous patient population, with some patients exhibiting endocrine resistance and an increased risk of recurrence. Among these high-risk subgroups, ERpHER2n Basal-like (ERpHER...

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Главные авторы:	Lennart Hohmann, Deborah F. Nacer, Mattias Aine, Yasin Memari, Daniella Black, Ramsay Bowden, Helen R. Davies, Åke Borg, Johan Vallon-Christersson, Serena Nik-Zainal, Johan Staaf
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-12-01
Серии:	Genome Medicine
Предметы:	ER-positive/HER2-negative breast cancer High-risk breast cancer PAM50 subtyping Gene expression profiling Basal phenotype Homologous recombination deficiency
Online-ссылка:	https://doi.org/10.1186/s13073-025-01576-9
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