Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase
Summary: The Piwi/Piwi-interacting RNA (piRNA) pathway protects genome integrity in animal germ lines. Maturation of piRNAs involves nucleolytic processing at both 5′ and 3′ ends. The ribonuclease PARN-1 and its orthologs mediate piRNA 3′ trimming in worms, insects, and mammals. However, the signifi...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2024-02-01
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| Serier: | Cell Reports |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2211124724000202 |
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