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Potential mechanism underlying HXSJ decoction in the treatment of venous leg ulcers: based on the association between venous leg ulcers and ferroptosis

Abstract Background Venous leg ulcer (VLU) is among the most severe clinical manifestations of chronic venous disease (CVD) and imposes substantial burdens on both patients and society. VLU pathogenesis is closely associated with the impairment of vascular endothelial cells. In this study, tissue sa...

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Main Authors: Sunfeng Pan, Lie Xiong, Jiakun Li, Zhenjun Wang, Yujuan Su, Gaofeng Fang, Minda Zhu, Hanqiang Shi, Jiayan Li, Zhaoyan Liu, Chunmao Han, Yanbo Shi
Format: Artigo
Language:Inglês
Published: BMC 2025-12-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Venous leg ulcer
Ferroptosis
Chinese herbal compound
Iron overload
HUVECs
Online Access:https://doi.org/10.1186/s12906-025-05184-3
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