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Empagliflozin improves renal injury of diabetic nephropathy complicated with hyperuricemia through AMPK by promoting autophagy and inhibiting apoptosis

Abstract Objective This study aimed to investigate how empagliflozin alleviates renal injury in diabetic nephropathy with hyperuricemia by activating AMPK and regulating autophagy and apoptosis. Methods This study incorporated clinical renal tissue samples, diabetic-hyperuricemic mouse models, and H...

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Principais autores: Zhiqin Zhang, Yanmei Xu, Chuanwen Xu, Qi Gao, Xiaoyan Wu, Ting Wu
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2026-01-01
coleção:Saudi Pharmaceutical Journal
Assuntos:
Diabetic nephropathy
Hyperuricemia
Empagliflozin
AMPK
Autophagy
Apoptosis
Acesso em linha:https://doi.org/10.1007/s44446-025-00054-y
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