HPS6 Regulates the Biogenesis of Weibel–Palade Body in Endothelial Cells Through Trafficking v-ATPase to Its Limiting Membrane

The Weibel–Palade body (WPB) is one of the lysosome-related organelles (LROs) in endothelial cells, whose main content is von Willebrand factor (vWF). The biogenesis of LROs is regulated by the Hermansky–Pudlak syndrome (HPS) protein-associated complexes through transporting cargo proteins to WPBs....

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Autori principali:	Jiran Lu, Jing Ma, Zhenhua Hao, Wei Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-02-01
Serie:	Frontiers in Cell and Developmental Biology
Soggetti:	Weibel–Palade body von Willebrand factor lysosome-related organelle Hermansky–Pudlak syndrome HPS6 v-ATPase
Accesso online:	https://www.frontiersin.org/articles/10.3389/fcell.2021.743124/full
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