Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis

Stress is well known to contribute to the development of both neurological and psychiatric diseases. In the central nervous system, a role for STING (stimulator of interferon genes) in modulating immunological responses has been widely suggested, and this protein possesses both neurotoxic and neurop...

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Detalhes bibliográficos

Principais autores:	Na Duan, Yanpeng Zhang, Shuwen Tan, Jianyu Sun, Mao Ye, Hui Gao, Kairui Pu, Meiyan Wu, Qiang Wang, Qian Zhai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-07-01
coleção:	Neurobiology of Disease
Assuntos:	Microglia Phagocytosis Interferon Neuroinflammation Chronic stress
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996122001310
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