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Improve BBB Penetration and Cytotoxicity of Palbociclib in U87-MG Glioblastoma Cells Delivered by Dual Peptide Functionalized Nanoparticles

Palbociclib (PBC) is an FDA-approved CDK4/6 inhibitor used for breast cancer treatment. PBC has been demonstrated its ability to suppress the proliferation of glioma cells by inducing cell cycle arrest. However, the efflux transporters on the blood-brain barrier (BBB) restricts the delivery of PBC t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yu-Chen Lo, Wen-Jen Lin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2023-10-01
Cyfres:Pharmaceutics
Pynciau:
Mynediad Ar-lein:https://www.mdpi.com/1999-4923/15/10/2429
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!