Exploring cell death mechanisms in spheroid cultures using a novel application of the RIP3-caspase3-assay

Abstract This study explores the application of the RIP3-caspase3-assay in heterogeneous spheroid cultures to analyze cell death pathways, emphasizing the nuanced roles of apoptosis and necroptosis. By employing directly conjugated monoclonal antibodies, we provide detailed insights into the complex...

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Bibliographic Details

Main Authors:	C. I. Philippi, J. Hagens, K. M. Heuer, H. C. Schmidt, P. Schuppert, L. Pagerols Raluy, M. Trochimiuk, Z. Li, M. J. Bunders, K. Reinshagen, C. Tomuschat
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2024-07-01
Series:	Scientific Reports
Subjects:	Organoids Cell death mechanisms RIP3-caspase3 assay TNFα -induced stress Apoptosis and necroptosis
Online Access:	https://doi.org/10.1038/s41598-024-66805-4
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