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Integrative Computational Approaches to Prostate Cancer with Conditional Reprogramming and AI-Driven Precision Medicine

Prostate cancer, particularly metastatic castration-resistant prostate cancer (mCRPC), presents therapeutic challenges rooted in adaptive lineage plasticity and neuroendocrine transdifferentiation. Conventional genome-based models fail to account for the divergent clinical trajectories observed amon...

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Principais autores: Ahmed Fadiel, Punit Malpani, Kenneth D. Eichenbaum, Frederick Naftolin, Aya Hassouneh, Geralyn Chong, Kunle Odunsi
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-04-01
Serier:Cells
Fag:
prostate cancer
conditional reprogramming
single-cell multi-omics
spatial transcriptomics
neuroendocrine transdifferentiation
physics-informed machine learning
Online adgang:https://www.mdpi.com/2073-4409/15/8/700
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