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Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacoki...

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מידע ביבליוגרפי
Principais autores: Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley 2025-03-01
סדרה:CPT: Pharmacometrics & Systems Pharmacology
גישה מקוונת:https://doi.org/10.1002/psp4.13292
תגים: הוספת תג
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