Lysosomal proteases are involved in generation of N-terminal huntingtin fragments

N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in vitro. Mutant htt expression stimulates autophagy and increases levels of lysosomal proteases. Here, we show that lysosomal proteases, cathepsins D, B and L, affected mhtt processing and levels of cleavage produc...

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Hlavní autoři:	Yun J. Kim, Ellen Sapp, Benjamin G. Cuiffo, Lindsay Sobin, Jennifer Yoder, Kimberly B. Kegel, Zheng-Hong Qin, Peter Detloff, Neil Aronin, Marian DiFiglia
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2006-05-01
Edice:	Neurobiology of Disease
Témata:	Huntingtin proteolysis Cathepsin D Cathepsins B and L Aspartyl proteases Cysteine proteases Cleavage products A and B
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996105003177
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