Mutant Isocitrate Dehydrogenase 1 Expression Enhances Response of Gliomas to the Histone Deacetylase Inhibitor Belinostat

Histone deacetylase inhibitors (HDACis) are drugs that target the epigenetic state of cells by modifying the compaction of chromatin through effects on histone acetylation. Gliomas often harbor a mutation of isocitrate dehydrogenase (IDH) 1 or 2 that leads to changes in their epigenetic state presen...

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Главные авторы:	Chi-Ming Chang, Karthik K. Ramesh, Vicki Huang, Saumya Gurbani, Lawrence R. Kleinberg, Brent D. Weinberg, Hyunsuk Shim, Hui-Kuo G. Shu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2023-05-01
Серии:	Tomography
Предметы:	glioblastoma HDAC IDH sMRI
Online-ссылка:	https://www.mdpi.com/2379-139X/9/3/77
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