Caloric restriction mimetics chlorogenic acid and fisetin as potential autophagy inducers targeting ATG101

Autophagy is an important cytoprotective process impaired in neurodegenerative diseases such as Alzheimer's disease. The initiation process is mediated by the protein kinase Unc-51-like kinase 1 (ULK1) complex. ATG101, a cytosolic protein, plays a pivotal role in initiating autophagy as a component...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Apoorv Sharma, Indu Kumari, Asimul Islam, Hridayesh Prakash, Amresh Prakash, Vijay Kumar
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-09-01
Schriftenreihe:	Biochemistry and Biophysics Reports
Schlagworte:	ATG101 CRM Autophagy Interactions Molecular dynamics simulation Gene expression
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2405580825001682
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