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Blocking ADP-ribosylation expands the anti-mycobacterial spectrum of rifamycins

ABSTRACT The clinical utility of rifamycins against non-tuberculous mycobacterial (NTM) disease is limited by intrinsic drug resistance achieved by ADP-ribosyltransferase Arr. By blocking the site of ribosylation, we recently optimized a series of analogs with substantially improved potency against...

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Principais autores: Uday S. Ganapathy, Tian Lan, Véronique Dartois, Courtney C. Aldrich, Thomas Dick
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2023-10-01
Serier:Microbiology Spectrum
Fag:
rifamycins
NTM
non-tuberculous mycobacteria
ADP-ribosylation
M. abscessus
M. chelonae
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.01900-23
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