Blocking ADP-ribosylation expands the anti-mycobacterial spectrum of rifamycins
ABSTRACT The clinical utility of rifamycins against non-tuberculous mycobacterial (NTM) disease is limited by intrinsic drug resistance achieved by ADP-ribosyltransferase Arr. By blocking the site of ribosylation, we recently optimized a series of analogs with substantially improved potency against...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2023-10-01
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| Serie: | Microbiology Spectrum |
| Soggetti: | |
| Accesso online: | https://journals.asm.org/doi/10.1128/spectrum.01900-23 |
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