WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination

Abstract Background Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein 1 (WSB1) plays a protective role in ischemic cells. This study aims to investigate the effects of WSB1 on myocardial ischemia–reperfusion (I...

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Hauptverfasser:	Lini Fang, Yang Tao, Guoying Che, Yongzi Yun, Min Ren, Yujie Liu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-02-01
Schriftenreihe:	Molecular Medicine
Schlagworte:	Myocardial ischemia–reperfusion WSB1 β-catenin GSK3β Ubiquitination
Online-Zugang:	https://doi.org/10.1186/s10020-024-00800-3
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