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In-situ gel bases ocular delivery system of Ganciclovir, in-vivo and in-vitro investigation

Abstract Ocular drug delivery is challenging due to the eye’s unique anatomy and physiology, which limit drug absorption and distribution. Traditional methods like eye drops have poor bioavailability and often require frequent dosing. In-situ gel systems, liquid formulations that transform into a ge...

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Principais autores: Susanta Paul, Subhabrota Majumdar, Mainak Chakraborty, Swarupananda Mukherjee, Nilanjan Sarkar, Bhupendra Prajapati, Nemat Ali, Abdullah F. AlAsmari, Shamama Nishat
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-05-01
Serier:BMC Pharmacology and Toxicology
Fag:
In situ gel
Poloxamer 407
Hydroxypropyl methylcellulose
Factorial design
Ganciclovir
Ocular drug delivery
Online adgang:https://doi.org/10.1186/s40360-025-00934-y
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