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Mapping protein interactions in the active TOM-TIM23 supercomplex

The TOM and TIM23 complexes facilitate the transport of nuclear-encoded proteins into the mitochondrial matrix. Here, the authors use a stalled client protein to purify the translocation supercomplex and gain insight into the TOM-TIM23 interface and the mechanism of protein handover from the TOM to...

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Autors principals: Ridhima Gomkale, Andreas Linden, Piotr Neumann, Alexander Benjamin Schendzielorz, Stefan Stoldt, Olexandr Dybkov, Markus Kilisch, Christian Schulz, Luis Daniel Cruz-Zaragoza, Blanche Schwappach, Ralf Ficner, Stefan Jakobs, Henning Urlaub, Peter Rehling
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2021-09-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-021-26016-1
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