Longitudinal characterization of mosaic chromosomal alterations identifies factors influencing clonal dynamics of leukocytes

Abstract Characterizing the variation in clonal trajectory of age-related mosaic chromosomal alterations (mCAs) in circulating leukocytes can identify etiologic factors influencing clonal expansion and hematologic malignancy risk. Here we scan whole blood-derived DNA of 56,324 participants from the...

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Detalhes bibliográficos

Principais autores:	Rebecca L. Kelly, Derek W. Brown, Weiyin Zhou, Aubrey K. Hubbard, Corey D. Young, Kara M. Barnao, Alyssa Klein, Diptavo Dutta, Aurélie Vogt, Jia Liu, Jiahui Wang, Wen-Yi Huang, Neal D. Freedman, Stephen J. Chanock, Paul S. Albert, Mitchell J. Machiela
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-07-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-75996-5
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