Bile Acids Activate YAP to Promote Liver Carcinogenesis
Elevated bile acid levels increase hepatocellular carcinoma by unknown mechanisms. Here, we show that mice with a severe defect in bile acid homeostasis due to the loss of the nuclear receptors FXR and SHP have enlarged livers, progenitor cell proliferation, and Yes-associated protein (YAP) activati...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Elsevier
2013-11-01
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| Sarja: | Cell Reports |
| Linkit: | http://www.sciencedirect.com/science/article/pii/S2211124713006141 |
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