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Unlocking the Secrets of Cancer Stem Cells with γ-Secretase Inhibitors: A Novel Anticancer Strategy

The dysregulation of Notch signaling is associated with a wide variety of different human cancers. Notch signaling activation mostly relies on the activity of the γ-secretase enzyme that cleaves the Notch receptors and releases the active intracellular domain. It is well-documented that γ-secretase...

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Principais autores: Maryam Ghanbari-Movahed, Zahra Ghanbari-Movahed, Saeideh Momtaz, Kaitlyn L. Kilpatrick, Mohammad Hosein Farzaei, Anupam Bishayee
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-02-01
Serier:Molecules
Fag:
cancer stem cells
γ-secretase
γ-secretase inhibitors
Notch signaling
cancer treatment
Online adgang:https://www.mdpi.com/1420-3049/26/4/972
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