RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells

Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli (APC), which constitutes the initiating event in t...

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Bibliografski detalji

Glavni autori:	Christoph Otto, Carolin Kastner, Stefanie Schmidt, Konstantin Uttinger, Apoorva Baluapuri, Sarah Denk, Mathias T. Rosenfeldt, Andreas Rosenwald, Florian Roehrig, Carsten P. Ade, Christina Schuelein‐Voelk, Markus E. Diefenbacher, Christoph‐Thomas Germer, Elmar Wolf, Martin Eilers, Armin Wiegering
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2022-08-01
Serija:	Molecular Oncology
Teme:	CRC CX5461 MIZ1 MYC ribosome RNAPOL1
Online pristup:	https://doi.org/10.1002/1878-0261.13265
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