Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
BRCA1 plays a critical role in homology-directed repair (HDR) of DNA double strand breaks, and the repair defect of BRCA1-mutant cancer cells is being targeted with platinum drugs and poly (ADP-ribose) polymerase (PARP) inhibitors. We have employed relatively simple and sensitive assays to determine...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
eLife Sciences Publications Ltd
2017-04-01
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| Σειρά: | eLife |
| Θέματα: | |
| Διαθέσιμο Online: | https://elifesciences.org/articles/21350 |
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