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Increased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia

BackgroundEmerging evidence argues that monocytes, circulating innate immune cells, are principal players in COVID-19 pneumonia. The study aimed to investigate the role of soluble (s)CD163 and sCD14 plasmatic levels in predicting disease severity and characterize peripheral blood monocytes and dendr...

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Autori principali: Maria Antonella Zingaropoli, Parni Nijhawan, Anna Carraro, Patrizia Pasculli, Paola Zuccalà, Valentina Perri, Raffaella Marocco, Blerta Kertusha, Guido Siccardi, Cosmo Del Borgo, Ambrogio Curtolo, Camilla Ajassa, Marco Iannetta, Maria Rosa Ciardi, Claudio Maria Mastroianni, Miriam Lichtner
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021-02-01
Serie:Frontiers in Immunology
Soggetti:
monocytes
dendritic cells
pDCs
mDCs
SARS-CoV-2
flow cytometry
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627548/full
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