Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome

Structural, functional, and molecular alterations in excitatory spines are a common hallmark of many neurodevelopmental disorders including intellectual disability and autism. Here, we describe an optimized methodology, based on combined use of DiI and immunofluorescence, for rapid and sensitive cha...

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Autors principals:	Luisa Speranza, Kardelen Dalım Filiz, Sarah Goebel, Carla Perrone-Capano, Salvatore Pulcrano, Floriana Volpicelli, Anna Francesconi
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-10-01
Col·lecció:	Biomedicines
Matèries:	DiIC<sub>18</sub> dendritic spines excitatory synapses synaptopodin Fragile X Syndrome <i>Fmr1</i> knockout mouse
Accés en línia:	https://www.mdpi.com/2227-9059/10/11/2692
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