Aging and Alzheimer’s: the critical role of mitochondrial dysfunction and synaptic alterations

Alzheimer’s disease is a progressive neurodegenerative disorder marked by cognitive decline, accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic dysfunction, and mitochondrial impairment. Despite multiple therapeutic strategies, currently available treatments only provide symptom...

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Detalhes bibliográficos

Principais autores:	Pinky, Zitin Wali, Neha, Prachi Tiwari, Mohamed El-Tanani, Syed Arman Rabbani, Suhel Parvez
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-01-01
coleção:	Frontiers in Synaptic Neuroscience
Assuntos:	aging Alzheimer’s disease bioenergetics synaptic plasticity mitochondrial free radical production and longevity
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnsyn.2025.1676317/full
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