Activation and Identification of a Griseusin Cluster in <i>Streptomyces</i> sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

<i>Streptomyces</i> are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by heterologously expressing transcriptional regulators...

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Hauptverfasser:	Charlotte Beck, Tetiana Gren, Francisco Javier Ortiz-López, Tue Sparholt Jørgensen, Daniel Carretero-Molina, Jesús Martín Serrano, José R. Tormo, Daniel Oves-Costales, Eftychia E. Kontou, Omkar S. Mohite, Erik Mingyar, Evi Stegmann, Olga Genilloud, Tilmann Weber
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-10-01
Schriftenreihe:	Molecules
Schlagworte:	transcriptional regulators biosynthetic gene cluster genome mining heterologous expression griseusin pyranonaphtoquinone
Online-Zugang:	https://www.mdpi.com/1420-3049/26/21/6580
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