Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress‐Associated Degradation of EZH2/MYC Axis

Abstract Despite substantial advances in the antitumor effects of annonaceous acetogenins (ACGs), the absence of a defined biological action mechanism remains a major barrier to their clinical application. Here, it is found that squamocin effectively depletes both EZH2 and MYC in multiple cancer cel...

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Principais autores:	Yin Zhu, Yurui Liu, Xiangtao Wang, Zhifeng Chen, Baojian Chen, Bingxin Hu, Tiane Tang, Haoran Cheng, Xinglong Liu, Yunshan Ning
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2025-04-01
Series:	Advanced Science
Assuntos:	annonaceous acetogenins endoplasmic reticulum stress response EZH2/MYC axis squamocin ubiquitin‐proteasome degradation system
Acceso en liña:	https://doi.org/10.1002/advs.202413120
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