Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

Abstract A hexanucleotide repeat expansion (HRE) within the chromosome 9 open reading frame 72 (C9orf72) gene is the most prevalent cause of amyotrophic lateral sclerosis/fronto-temporal dementia (ALS/FTD). Current evidence suggests HREs induce neurodegeneration through accumulation of RNA foci and/...

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Principais autores:	Matthew P. Shaw, Adrian Higginbottom, Alexander McGown, Lydia M. Castelli, Evlyn James, Guillaume M. Hautbergue, Pamela J. Shaw, Tennore M. Ramesh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-11-01
coleção:	Acta Neuropathologica Communications
Assuntos:	Amyotrophic lateral sclerosis C9orf72 SOD1 TDP-43 Zebrafish Drug-screening
Acesso em linha:	http://link.springer.com/article/10.1186/s40478-018-0629-7
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