Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressors

Summary: Huntington’s disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT) resulting in expression of mutant HTT proteins (mHTT) with extended polyglutamine tracts, including in striatal neurons and astrocytes. It is unknown whether pathophysiology in vivo can be attenuated by...

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Autors principals:	Mohitkumar R. Gangwani, Joselyn S. Soto, Yasaman Jami-Alahmadi, Srushti Tiwari, Riki Kawaguchi, James A. Wohlschlegel, Baljit S. Khakh
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-01-01
Col·lecció:	Cell Reports
Matèries:	CP: Neuroscience
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S221112472201854X
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