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Role of CD38 in anti-tumor immunity of small cell lung cancer

IntroductionImmune checkpoint blockade (ICB) with or without chemotherapy has a very modest benefit in patients with small cell lung cancer (SCLC). SCLC tumors are characterized by high tumor mutation burden (TMB) and low PD-L1 expression. Therefore, TMB and PD-L1 do not serve as biomarkers of ICB r...

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Hauptverfasser: Hirokazu Taniguchi, Shweta S. Chavan, Andrew Chow, Joseph M. Chan, Hiroshi Mukae, Charles M. Rudin, Triparna Sen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2024-03-01
Schriftenreihe:Frontiers in Immunology
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1348982/full
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