Evaluation of lethality and cytotoxic effects induced by Naja ashei (large brown spitting cobra) venom and the envenomation-neutralizing efficacy of selected commercial antivenoms in Kenya

Neutralization of lethality in mice model at the preclinical level has been established by the World Health Organization as the gold standard for the evaluation of antivenom efficacy. The assessment of the neutralization profiles of antivenoms helps to discern the efficacy or otherwise of these anti...

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Главные авторы:	Ernest Z. Manson, Mutinda C. Kyama, Joseph K. Gikunju, Josephine Kimani, James H. Kimotho
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2022-06-01
Серии:	Toxicon: X
Предметы:	Preclinical efficacy Antivenoms Naja ashei Median lethal dose Minimum necrotizing dose Minimum edema-forming dose
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2590171022000352
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