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Intradermally injected abobotulinumtoxinA administered preemptively before surgery alleviates post-surgical pain and normalizes behavior in a translational animal model

Abstract Previously, abobotulinumtoxinA (aboBoNT-A) injected intraoperatively resulted in effective, but delayed post-surgical analgesia in pigs. Here, we explore the efficacy of preemptively administered aboBoNT-A in intact animals on pain and associated behaviors following a full-skin-muscle incis...

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Kaydedildi:
Asıl Yazarlar: Mikhail Kalinichev, Sylvie Cornet, David Castel, Sigal Meilin, Ron Horne, Laurent Pons, Stephen M. Evans, Stephane Lezmi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2025-02-01
Seri Bilgileri:Scientific Reports
Konular:
Botulinum neurotoxin
Postsurgical pain
Juvenile pigs
Anxiety
Depression
Online Erişim:https://doi.org/10.1038/s41598-025-90886-4
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