Molecular profiling of ex vivo prostate cancer CAF models captures stromal heterogeneity and drug vulnerabilities

Abstract Cancer-associated fibroblasts (CAFs) are central architects of the prostate cancer (PCa) microenvironment, yet their phenotypic diversity and druggable vulnerabilities remain largely uncharted. Here, we present an integrative multi-omics characterization of primary ex vivo CAFs from seven t...

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書誌詳細

主要な著者:	Frida Rantanen, Astrid Murumägi, Mariliina Arjama, Katja Välimäki, Elina Multamäki, Tuomas Mirtti, Antti Rannikko, Teijo Pellinen, Daniela Ungureanu, Olli Kallioniemi
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Publishing Group 2025-11-01
シリーズ:	Cell Death Discovery
オンライン･アクセス:	https://doi.org/10.1038/s41420-025-02792-3
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