Pan-carcinoma sialyl-Tn-targeting expands CAR therapy to solid tumors

Summary: Accurate identification of tumor-specific markers is vital for developing chimeric antigen receptor (CAR)-based therapies. While cell surface antigens are seldom cancer-restricted, their post-translational modifications (PTMs), particularly aberrant carbohydrate structures, offer attractive...

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Principais autores:	Rafaela Abrantes, Christopher Forcados, David J. Warren, Liliana Santos-Ferreira, Karianne Giller Fleten, Emanuel Senra, Ana Filipa Costa, Klara Krpina, Rui Henrique, Ann Magritt Liberg, Puneet Rawat, Pascal Gelebart, Emmet McCormack, Line Bjørge, Ben Davidson, Victor Greiff, Daniela Elena Costea, Filipe Pinto, Kjersti Flatmark, Catarina Gomes, Else Marit Inderberg, Celso A. Reis, Sébastien Wälchli
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2025-09-01
叢編:	Cell Reports Medicine
主題:	immunotherapy CAR T cells glycosylation sialyl-Tn cancer antibodies
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2666379125004239
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