Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review

Cullin 4B (CUL4B), a pivotal member of the Cullins protein family, plays a crucial role in immune regulation and has garnered significant research attention. CUL4B, through the Cullin 4B-RING E3 ubiquitin ligase (CRL4B) complex, regulates CD4+ T cell differentiation, fostering a balance between TH1...

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Principais autores:	Siyu He, Ziyue Wang, Yinan Zhu, Mingfang Sun, Xuyong Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-03-01
coleção:	Frontiers in Immunology
Assuntos:	CUL4B immune system CRL4B cancer immunology epigenetic regulation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1473817/full
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