Clinical and pathophysiological roles of lower lobe–dominant mucus plugs on computed tomography in patients with asthma with and without bronchiectasis

Background: Despite the clinical relevance of mucus plugging, the role of spatial distribution of mucus plugs remains unclear in patients with asthma. Objective: We sought to examine whether greater lower lobe mucus plug dominance is associated with more clinical and pathophysiological impairments i...

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Principais autores:	Naoya Tanabe, MD, PhD, Hisako Matsumoto, MD, PhD, Natsuko Nomura, MD, PhD, Yusuke Hayashi, MD, Ryo Sakamoto, MD, PhD, Mikio Toyoshima, MD, PhD, Osamu Matsuno, MD, PhD, Toshiyuki Kita, MD, PhD, Nobuyuki Hizawa, MD, PhD, Takuro Sakagami, MD, PhD, Koichi Fukunaga, MD, PhD, Mari Miki, MD, PhD, Naozumi Hashimoto, MD, PhD, Noboru Hattori, MD, PhD, Sumito Inoue, MD, PhD, Kazuto Matsunaga, MD, PhD, Kojiro Otsuka, MD, PhD, Takahiro Tsuburai, MD, PhD, Hiroaki Iijima, MD, PhD, Hiroyuki Nagase, MD, PhD, Morio Nakamura, MD, PhD, Tetsuji Kawamura, MD, Takashi Kijima, MD, PhD, Taisuke Tsuji, MD, Hironobu Sunadome, MD, PhD, Susumu Sato, MD, PhD, Atsuyasu Sato, MD, PhD, Toyohiro Hirai, MD, PhD
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-11-01
Series:	Journal of Allergy and Clinical Immunology: Global
Assuntos:	Asthma comorbid bronchiectasis exacerbations exhaled nitric oxide lower lobe dominance lung function
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2772829325001675
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