Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.

Elevation of the second messenger cGMP by nitric oxide (NO) activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals. The NO-cGMP-PKG signaling pathway is also a major therapeutic target for cardiovascular and male repr...

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Autori principali:	Yan Hao, Ningyi Xu, Andrew C Box, Laura Schaefer, Kasthuri Kannan, Ying Zhang, Laurence Florens, Christopher Seidel, Michael P Washburn, Winfried Wiegraebe, Ho Yi Mak
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2011-05-01
Serie:	PLoS Genetics
Accesso online:	http://europepmc.org/articles/PMC3088716?pdf=render
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