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Investigating the causal relationship and potential shared diagnostic genes between primary biliary cholangitis and systemic lupus erythematosus using bidirectional Mendelian randomization and transcriptomic analyses

BackgroundThe co-occurrence of primary biliary cholangitis (PBC) and systemic lupus erythematosus (SLE) has been consistently reported in observational studies. Nevertheless, the underlying causal correlation between these two conditions still needs to be established.MethodsWe performed a bidirectio...

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Principais autores: Tian Tao, Anqi Tang, Lizeyu Lv, Jianhua Yuan, Ling Wu, Liangbin Zhao, Jun Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-02-01
coleção:Frontiers in Immunology
Assuntos:
systemic lupus erythematosus
primary biliary cholangitis
Mendelian randomization
transcriptomic data
causal relationship
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1270401/full
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