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Integrated transcriptomic and metabolomic analysis of the antibacterial mechanism of Rhizoma Coptidis extract against Staphylococcus epidermidis ATCC 35984

Abstract Background Biofilm formation is a key virulence factor in Staphylococcus epidermidis. Rhizoma Coptidis, the medicinal root of Coptis chinensis, has been traditionally used in Chinese medicine for its broad-spectrum antimicrobial properties. Results This study investigated the antibacterial...

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Principais autores: Lizhuang Wang, Yan Xing, Shuai Yang, Huan Zhang, Laiji Ma, Li Shao
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-08-01
Serier:BMC Microbiology
Fag:
Rhizoma Coptidis extract
Staphylococcus epidermidis
Antibacterial activity
Biofilm
Transcriptomic
Metabolomic
Online adgang:https://doi.org/10.1186/s12866-025-04169-z
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