Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin

ABSTRACTDuring blood-stage infection, Plasmodium falciparum parasites are constantly exposed to a range of extracellular stimuli, including host molecules and drugs such as artemisinin derivatives, the mainstay of artemisinin-based combination therapies currently used as first-line treatment worldwi...

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Autors principals:	Lucien Platon, Didier Leroy, David A. Fidock, Didier Ménard
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2024-04-01
Col·lecció:	Microbiology Spectrum
Matèries:	malaria P. falciparum ring stages temporary cell growth arrest artemisinin resistance intercellular communication
Accés en línia:	https://journals.asm.org/doi/10.1128/spectrum.03500-23
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