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ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells

Aging and inflammation: aging cells express interferon-stimulated genes in a non-canonical pathway Aging cells express many kinds of inflammation-related genes called SASP (senescence-associated secretary-phenotype), which are involved in aging-associated phenotypes. However, the underlying molecula...

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Huvudupphov: Mari Yamagami, Motoyuki Otsuka, Takahiro Kishikawa, Kazuma Sekiba, Takahiro Seimiya, Eri Tanaka, Tatsunori Suzuki, Rei Ishibashi, Motoko Ohno, Kazuhiko Koike
Materialtyp: Artigo
Språk:Inglês
Utgiven: Nature Portfolio 2018-11-01
Serie:npj Aging and Mechanisms of Disease
Länkar:https://doi.org/10.1038/s41514-018-0030-6
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