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A novel interoceptive subfornical organ to infralimbic cortex mechanism relays airway inflammation effects on fear extinction

Abstract There is growing interest in the impact of internal body states on the brain and behavior. The detrimental effects of chronic lung inflammation on mental health are well recognized; however, underlying mechanisms are not known. Here, using a murine model of allergic asthma we report comprom...

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Principais autores: Emily Allgire, Jaclyn W. McAlees, Rebecca A. Ahlbrand, Elizabeth Mancz, Lauren L. Vollmer, Andrew Winter, Katherine M.J. McMurray, Laura Maile, Bryan Sanders, William G. Ryan, Allan-Hermann Pool, Igal Ifergan, Eric S. Wohleb, Steve Davidson, Robert E. McCullumsmith, Ian P. Lewkowich, Renu Sah
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-05-01
Serier:Journal of Neuroinflammation
Fag:
Airway inflammation
Fear
Subfornical organ
Infralimbic cortex
Microglia
Interleukin 17A
Online adgang:https://doi.org/10.1186/s12974-026-03834-y
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