Preclinical evaluation of long-acting cabotegravir and rilpivirine for HIV post-exposure prophylaxis in a macaque modelResearch in context

Summary: Background: Current guidelines for post-exposure prophylaxis (PEP) recommend 28 days of daily oral antiretroviral drugs. However, low adherence and inadequate regimen completion represent important challenges. We investigated in macaques whether a single injection of the combination of lon...

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主要な著者:	Priya Srinivasan, Jining Zhang, Tiancheng Edwards, Chuong Dinh, Ayanna Green, Dawn Little, Tyana Singletary, Maria Mendoza, Yi Pan, Frank Deyounks, Ryan Johnson, Jonathan Lipscomb, Athena P. Kourtis, Walid Heneine, J. Gerardo García-Lerma, James M. Smith
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2026-01-01
シリーズ:	EBioMedicine
主題:	HIV post-exposure prophylaxis Macaque models Long-acting injectables Cabotegravir (CAB) Rilpivirine (RPV)
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2352396425005110
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